Molecular diagnosis of visceral herpes zoster


Menno D de Jong, Jan F L weel, Marinus H J van Oers, Rene Boom, Pauline M E Wertheim-van Dillen

 

Patients with disseminated herpes zoster may present with severe abdominal pain that results from visceral involement of varicella-zoster-virus Infection. in the absence of cutaneous eruptions of herpes zoster, visceral herpes zoster is extremely difficult to diagnose. This diagnostic diffisulty has the potential to cause devastating delays in treatment.

we report a case series of four patients with visceral herpes zoster in whom large concentrations of DNA from varicella zoster virus were detectable in blood by PCR before signs of infection appeared on the skin, thus enabling early diagnosis and treatment.


THE LANCENT . VOL 357. JUNE 30,2001