Investigation prevalence of MRSA* colonies in neonates


1-      Professor M.H. Soltanzadeh MD Professor of pediatrics MD , Shaheed Beheshti university of medical sciences , Tehran , Iran  , ID,  Mayo clinic

2-      Dr Arbabi Assistant Professor of pediatrics , Iran university Tehran , Iran 

3-     Dr Shirvani Assistant Professor of pediatrics, ID , Shaheed Beheshti university
of medical sciences ,  Tehran , Iran

4-      Dr Radfar  Assistant Professor of pediatrics, Neonatologist , Shaheed Beheshti university of medical sciences ,  Tehran , Iran

5-  Dr Khodami     Assistant Professor of Clinical Patrhology  , Shaheed Beheshti
 university of medical sciences , 
Tehran , Iran

6-  Dr mirnia     Resident of Pediatrics . Shaheed Beheshti university of medical


BACKGROUND:Penicillin was introduced for s-aureus treatment in 1940.with the over usage of generations of this antibiotic resistant s-aureus were increased ;so that secondary resistance to these

Antibiotics was introduced in 1960.In 1970 decade MRSA was known as a major nosocomial infection leading to death. due to this problem we studied epidemiological prevalence colonization of s-aureus in two hospital centers of Imam Hossein and Akbarabadi on 100 neonates in 2002.

METHOD: Skin and umbilical culture was obtained from 100 new born in two hospital
center after 72hr admission with a sterile cotton swap.they were planted in sheep
blood agar ,organisms were studied for methicillin resistant and meticillin sensitive
s-aureus(MRSA and MSSA**). In order to screen MRSA, all of the isolates were
cultured on muller hinton with Nacl %4 containing 6 microg/cc oxacillin.The results
 were recorded in questioners and with other epidemiologic informations were
analyzed by SPSS 10 software.

RESULTS:  prevalence of s-aureus was %46 that %51 were male and %49 were female.
%54 had an apgar score of first minute below 7.%57were delivered by NVD*** and the
rest were cesarean sectioned. The most common basic disease was RDS %27 and sepsis
 %13.%23 of the neonates were intubated.blood culture was positive in %28.%54 of the
 neonates had a birth weight below 2500.There was a significant relation between s-aureus colonization and blood culture p<004.%7 of the colonies were sensitive to cloxacillin and
 %92 were sensitive to vacomycin.%1resistant to vancomycin was seen.

CONCLUSION:  MRSA colonization is an important predictor for nonresponsive antibiotic
therapy in s-aureus nosocomial infections.use of antibiotic electually based on colonies
 resistant pattern is recommended.

*MRSA: meticillin resistant staph. Aureus

**MSSA: meticillin sencitive staph aureus

***NVD : normal vaginal delivery

Home page  | Introduction |  Research Studies  |  Editorships  |  Translations  |  Conferences 

Contact Information  |  Articles  |  Scientific meets & events  |  Research projects  |  Theses