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Investigation prevalence of MRSA* colonies in neonates
1-
Professor M.H. Soltanzadeh MD
Professor of pediatrics MD , Shaheed Beheshti university of medical
sciences ,
Tehran , Iran , ID, Mayo clinic
2-
Dr Arbabi Assistant Professor of pediatrics ,
Iran university Tehran , Iran
3-
Dr Shirvani Assistant Professor of pediatrics, ID , Shaheed Beheshti
university
of medical sciences , Tehran , Iran
4-
Dr Radfar Assistant Professor of pediatrics,
Neonatologist , Shaheed Beheshti university of medical sciences ,
Tehran , Iran
5-
Dr Khodami
Assistant Professor of Clinical Patrhology , Shaheed Beheshti
university of medical sciences ,
Tehran , Iran
6-
Dr mirnia
Resident of Pediatrics . Shaheed Beheshti university of medical
sciences
Abstract
BACKGROUND:Penicillin was
introduced for s-aureus treatment in 1940.with the over usage of
generations of this antibiotic resistant s-aureus were increased ;so
that secondary resistance to these
Antibiotics was introduced in 1960.In 1970 decade MRSA was known as
a major nosocomial infection leading to death. due to this problem
we studied epidemiological prevalence colonization of s-aureus in
two hospital centers of Imam Hossein and Akbarabadi on 100 neonates
in 2002.
METHOD: Skin
and umbilical culture was obtained from 100 new born in two
hospital
center after 72hr admission with a sterile cotton swap.they were
planted in sheep
blood agar ,organisms were studied for methicillin resistant and
meticillin sensitive
s-aureus(MRSA and MSSA**). In order to screen MRSA, all
of the isolates were
cultured on muller hinton with Nacl %4 containing 6 microg/cc
oxacillin.The results
were recorded in questioners and with other epidemiologic informations
were
analyzed by SPSS 10 software.
RESULTS:
prevalence of s-aureus was %46 that %51 were male and %49 were
female.
%54 had an apgar score of first minute below 7.%57were delivered by
NVD*** and the
rest were cesarean sectioned. The most common basic disease was RDS
%27 and sepsis
%13.%23 of the neonates were intubated.blood culture was positive in
%28.%54 of the
neonates had a birth weight below 2500.There was a significant relation
between s-aureus colonization and blood culture p<004.%7 of the
colonies were sensitive to cloxacillin and
%92 were sensitive to vacomycin.%1resistant to vancomycin was seen.
CONCLUSION:
MRSA colonization is an important predictor for nonresponsive
antibiotic
therapy in s-aureus nosocomial infections.use of antibiotic
electually based on colonies
resistant pattern is recommended.
*MRSA: meticillin resistant staph.
Aureus
**MSSA: meticillin sencitive staph aureus
***NVD : normal vaginal delivery | 
