Brucellosis, Treatment
Prolonged therapy for achieving a cure.
Oral Doxycycline is the most useful antimicrobial agent.2-4 mg/kg per day max 200 mg /d in 2 dose alternatively, Tetracycline 30-40 mg /kg/d max 2g/d in 4 dose for 4-6 wks.

 

Treatment conti.
< 8 yrs :  TMP- SMX 10 mg /kg/d of Trimetoprim max 480 mg d& 50 mg /k /d of Sulfamethoxazol max 2-4g/d PO for 45 d
  Plus ; Rifampin  15-20 mg/kg/d PO  max 600-900 mg /d for 45 d
> 8 yrs : Doxycycline for 6 wks PO  Plus
   Streptomycin 20 mg /kg /d in 2 dose max 1 g/d IM or Gentamycin 3-5 mg/kg /d for 1-2 wks alternative ; Doxycycline for 6 wks plus Rif 6 wks
 

Meningitis,Osteomyelitis, Endocarditis

     Doxycycline 4-6 mo or TRM-SMX  Plus ;
    
Streptomycin for 4-6 mo or Gentamycin 7-14 d
     Plus/minus
   Rifampin < 8 yrs > 8 yrs PO for 4-6 mo
   The benefit of Steroid in Neurobrucellosis is unpruven.