Prolonged
therapy for achieving a cure. Oral Doxycycline is
the most useful antimicrobial agent.2-4 mg/kg per day max 200 mg /d
in 2 dose alternatively, Tetracycline 30-40 mg /kg/d max 2g/d in 4
dose for 4-6 wks.
Treatment conti.
< 8 yrs : TMP- SMX 10 mg /kg/d of Trimetoprim
max 480 mg d& 50 mg /k /d of
Sulfamethoxazol max 2-4g/d PO for 45 d Plus ; Rifampin 15-20 mg/kg/d PO max 600-900 mg /d for
45 d > 8 yrs : Doxycycline for 6 wks PO Plus Streptomycin 20 mg /kg /d in 2 dose max 1 g/d IM or
Gentamycin 3-5 mg/kg /d for 1-2 wks alternative ; Doxycycline for 6 wks plus Rif
6 wks
Meningitis,Osteomyelitis,
Endocarditis
Doxycycline 4-6 mo or TRM-SMX Plus ;
Streptomycin for 4-6 mo or Gentamycin 7-14 d Plus/minus
Rifampin < 8 yrs > 8 yrs PO for 4-6 mo
The benefit of Steroid in Neurobrucellosis is unpruven.
