Inflammatory Cells in Asthma
The lungs can be considered to comprise of
foure compartments in which leukocytes ate found: lumen, Epithelium,
Interstitial spaces and bronchus associated lymphoid tissue (BALT).
The majority of organized lymphoid tissue in the lung is in the form
of follicles that are located throughout the bronchial tree, named the
BALT. The lung parenchyma normally contains few lymphoid cells.
Pulmonary lymphoid cells are predominantly of memory phenotype
sparsely distributed along the submucosa and lamina propria. Lymphoid
effector cells are also present above the epithelium membrane between
the epithelium cells and within the intersitium. During the
inflammatory process in asthma , the picture changes quite markedly ,
with lymphocyte and eosinophil infiltration into the bronchial mucosa.
Based on the recent findings, We try to clarify the phenotype and
activities of T lymphocytes, characteristics functions of
intraepithelial lymphocytes (IEL), role of inflammatory cytokines and
chemokines , expression of adhesion molecules (such as ICAM-1 and
VCAM-1) , role of dendritic cells in T lymphocyte selection and
activation , and so on.