Role of Allergens in Asthma
Summary
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Because of the pandemic in
both the prevalence and morbidity of asthma , there is a need for
understanding the basis of allergy development and to develop effective
allergy prevention strategies . Potential strategies involve modulating
the principal factors responsible for the atopic state through genetic ,
immunologic , and environmental manipulation . However , at present the
best way for preventing asthma is through environmental controls in
attempt to reduce patient exposure . A particularly critical time is early
infancy . Although , prenatal identification of infants most at risk for
allergic disease is ideal.
Allergens are
macromolecules , usually proteinaceous or glycopproteins in nature , that
sensitize the host forproducing specific IgE antibodies and allergic
reactions.
Most naturally occuring
allergens share common charaqcteristics : molecular weights 10-70 Kd,
foreignness for host , stability in soluble from and solubility in fluids
.
Particles dervied from seed
plants and fungi , as well as certain algae , bacteria , actinomycetes ,
and protozoa , regularly undergo atmospheric transport . The resulting
aerosols very with land use and cucles of plant growth. Additional
biogenic debris . including mammalian danders and arthropod emanations
also serve as airborne allergens ( aeroallergens )
There are different factors
to determine allergenisity including : concentration of allergens ,
temperature and humidity . Concentration of indoor allergens could be more
than outdoor allergens.
A greater understanding of the genetic
and immunologic basis of atopy will surely lead to new and better
strategies to prevent asthma . An “Allergy Prevention Bill of Rights”
could include the right to be free from ETS (Environmental Tobacco
Smoke): the right to breathe clean , unpolluted air : the right to
breast-fed not formula-fed : and the right to information regarding the
possible risks associated with exposure to pets and house dust mites.
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