Aeroirriants have a significant role in asthma aggravation in patients of all ages. They can be divided in two major categories as outdoor and indoor air pollutants . Besides tobacca smoke is one of the greatest irritants.
The role of air pallution , including the toxic substances in the atmosphere has been the subject of many investigations during recent years. Diesel particles can enhance the serum IgE level and modulate cytokine productions and perhapse theay are one of the important factors for worldwide increasing prevalence of asthma. In industerialized areas there are several aeropollutants from fossil fuels combustion like sulfur dioxide , ozone , lead , carbon monoxid , partiulate matter , and oxides of of nitrogen which increase bronchial reactivity. This broncial reactivity , in turn induces induce vulnerability in asthmatic patients to some other allergens , irritants and infectious agents. Ozone and sulfur dioxide may produce bronchospasm in the high abnormal concentration especially during exercise.
Other aeroirritants may impact their role in the home, including fumes
from gas cooking and heating . dusts and fumes from chemical cleaning ,
painting , fresh newsprints, smoke from fire places, volatile organic
compound , hair sprays and perfumes. Frequently the asthmatic recognize a
correlation of the asthmatic symptoms and the aero pollutant patients
Tobacco smoke is the major indoor air pollutant. Tobacco smoke increases allergic sensitization, asthma and other respiratory diseases. In multiple studies , it has been shown that serum IgE and prevalence of positive skin text toward aeroallergens , and occupational allergens , increased with tobacco smoking.
Infants and young children are particularly susceptible to the effects of tobacco smoke as passive smokers. Children of parents who smoke may be sensitized , develop wheezing , and have earlier onset of allergy and asthma than children of nonsmoking parents.
Passive smoking is the best identified risk factor for the development
of allergic disease, particularly in early childhood.